Recurrent implantation failure refers to failure to achieve a clinical pregnancy after transfer of
at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman …

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …

The relationship between the ATP content of mature human oocytes and developmental
potential after uterine transfer of sibling embryos was examined in 20 non-male factor in …

This review considers how our understanding of preimplantation embryo metabolism has
progressed since the pioneering work on this topic in the late 1960s and early 1970s …

In human in-vitro fertilization (IVF) embryos are routinely transferred to the uterus on day 2 or
day 3 of development. Resultant implantation and pregnancy rates are disappointingly low …

STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in
embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight …

The development of 181 surplus human embryos, including both normally and abnormally
fertilized, was observed from day 2 to day 5, 6 or 7 in vitro. 63/149 (42%) normally fertilized …

Objective To determine the levels of metabolites surrounding the human oocyte and embryo
in vivo. Design Oviduct and uterine fluids were collected throughout the menstrual cycle …

A single cell was removed, through a hole made in the zona pellucida, from each of 30
human embryos at the 6-10 cell cleavage stage three days after in-vitro fertilisation. A …