Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …

▪ Abstract Dendritic cells (DCs) have several functions in innate and adaptive immunity. In
addition, there is increasing evidence that DCs in situ induce antigen-specific …

The recent success of immunotherapies has highlighted the power of leveraging the
immune system in the fight against cancer. In order for most immune‐based therapies to …

Myeloid antigen-presenting cells (APC) are known to cross-present exogenous antigen on
major histocompatibility class I molecules to CD8+ T cells and thereby induce protective …

The immune system generally avoids horror autotoxicus or autoimmunity, an attack against
the body's own constituents. This avoidance requires that self-reactive T cells be actively …

T cell receptor (TCR) ligation is required for the extrathymic differentiation of forkhead box
p3+ (Foxp3+) regulatory T cells. Several lines of evidence indicate that weak TCR …

Peripheral immune tolerance is believed to be induced by the processing and presentation
of self-tissues that die during physiologic tissue turnover. To examine the mechanism that …

Current therapies for autoimmune diseases rely on traditional immunosuppressive
medications that expose patients to an increased risk of opportunistic infections and other …

After recognition of Ag/MHC and ligation of a costimulatory molecule, resting T cells will
clonally expand and then delete to very low levels. Previously, it was shown that deletion …

An evaluation of potential antibody formation to biologic therapeutics during the course of
nonclinical safety studies and its impact on the toxicity profile is expected under current …