Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review

A Astrup, F Magkos, DM Bier, JT Brenna… - Journal of the American …, 2020 - jacc.org
The recommendation to limit dietary saturated fatty acid (SFA) intake has persisted despite
mounting evidence to the contrary. Most recent meta-analyses of randomized trials and …

[HTML][HTML] Recent insights into mechanisms of β-cell lipo-and glucolipotoxicity in type 2 diabetes

M Lytrivi, AL Castell, V Poitout, M Cnop - Journal of molecular biology, 2020 - Elsevier
The deleterious effects of chronically elevated free fatty acid (FFA) levels on glucose
homeostasis are referred to as lipotoxicity, and the concurrent exposure to high glucose may …

Human gut microbes impact host serum metabolome and insulin sensitivity

HK Pedersen, V Gudmundsdottir, HB Nielsen… - Nature, 2016 - nature.com
Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2
diabetes. Here we show how the human gut microbiome impacts the serum metabolome …

Food groups and risk of type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies

L Schwingshackl, G Hoffmann, AM Lampousi… - European journal of …, 2017 - Springer
The aim of this systematic review and meta-analysis was to synthesize the knowledge about
the relation between intake of 12 major food groups and risk of type 2 diabetes (T2D). We …

Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: a comprehensive review

D Mozaffarian - Circulation, 2016 - Am Heart Assoc
Suboptimal nutrition is a leading cause of poor health. Nutrition and policy science have
advanced rapidly, creating confusion yet also providing powerful opportunities to reduce the …

Association of dairy intake with cardiovascular disease and mortality in 21 countries from five continents (PURE): a prospective cohort study

M Dehghan, A Mente, S Rangarajan, P Sheridan… - The Lancet, 2018 - thelancet.com
Background Dietary guidelines recommend minimising consumption of whole-fat dairy
products, as they are a source of saturated fats and presumed to adversely affect blood …

A metabolomics comparison of plant-based meat and grass-fed meat indicates large nutritional differences despite comparable Nutrition Facts panels

S van Vliet, JR Bain, MJ Muehlbauer, FD Provenza… - Scientific reports, 2021 - nature.com
A new generation of plant-based meat alternatives—formulated to mimic the taste and
nutritional composition of red meat—have attracted considerable consumer interest …

Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis …

RJ De Souza, A Mente, A Maroleanu, AI Cozma, V Ha… - Bmj, 2015 - bmj.com
Objective To systematically review associations between intake of saturated fat and trans
unsaturated fat and all cause mortality, cardiovascular disease (CVD) and associated …

Functional roles of fatty acids and their effects on human health

PC Calder - Journal of parenteral and enteral nutrition, 2015 - Wiley Online Library
A variety of fatty acids exists in the diet of humans, in the bloodstream of humans, and in
cells and tissues of humans. Fatty acids are energy sources and membrane constituents …