Improving the replicability of neuroimaging findings by thresholding effect sizes instead of p‐values

SN Vandekar, J Stephens - Human Brain Mapping, 2021 - Wiley Online Library
The classical approach for testing statistical images using spatial extent inference (SEI)
thresholds the statistical image based on the p‐value. This approach has an unfortunate …

Robust spatial extent inference with a semiparametric bootstrap joint inference procedure

SN Vandekar, TD Satterthwaite, CH Xia… - …, 2019 - academic.oup.com
Spatial extent inference (SEI) is widely used across neuroimaging modalities to adjust for
multiple comparisons when studying brain-phenotype associations that inform our …

Multiple comparison correction methods for whole-body magnetic resonance imaging

E Breznik, F Malmberg, J Kullberg… - Journal of Medical …, 2020 - spiedigitallibrary.org
Purpose: Voxel-level hypothesis testing on images suffers from test multiplicity. Numerous
correction methods exist, mainly applied and evaluated on neuroimaging and synthetic …

Targeting intra‐tumoral heterogeneity of human brain tumors with in vivo imaging: A roadmap for imaging genomics from multiparametric MR signals

JG Parker, M Servati, EE Diller, S Cao, C Ho… - Medical …, 2023 - Wiley Online Library
Resistance of high grade tumors to treatment involves cancer stem cell features,
deregulated cell division, acceleration of genomic errors, and emergence of cellular variants …

Exploring concomitant neuroimaging and genetic alterations in patients with and patients without auditory verbal hallucinations: a pilot study and mini review

H Yu, W Ying, G Li, X Lin, D Jiang… - Journal of …, 2020 - journals.sagepub.com
Objective To explore concomitant neuroimaging and genetic alterations in patients with
schizophrenia with or without auditory verbal hallucinations (AVHs), and to discuss the use …

Control of false positive rates in clusterwise fMRI inferences

F Zhang, J Gou - Journal of Applied Statistics, 2019 - Taylor & Francis
Random field theory (RFT) provided a theoretical foundation for cluster-extent-based
thresholding, the most widely used method for multiple comparison correction of statistical …

A local group differences test for subject-level multivariate density neuroimaging outcomes

JD Dworkin, KA Linn, AJ Solomon… - …, 2021 - academic.oup.com
A great deal of neuroimaging research focuses on voxel-wise analysis or segmentation of
damaged tissue, yet many diseases are characterized by diffuse or non-regional …

Using Minimally-Invasive In vivo Imaging to Map the Genomic Heterogeneity of Human Brain Tumors

M Servati - 2024 - hammer.purdue.edu
Human brain tumors present significant challenges due to their heterogeneous nature,
known as intra-tumoral heterogeneity (ITH), which evolves over space and time, leading to …

Handling multiplicity in neuroimaging through Bayesian lenses with hierarchical modeling

G Chen, Y Xiao, PA Taylor, T Riggins, F Geng… - bioRxiv, 2017 - biorxiv.org
In neuroimaging, the multiplicity issue may sneak into data analysis through several
channels, affecting expected false positive rates (FPRs; type I errors) in diverse ways. One …

Robust spatial extent inference with a semiparametric bootstrap joint testing procedure

SN Vandekar, TD Satterthwaite, CH Xia… - arXiv preprint arXiv …, 2018 - arxiv.org
Spatial extent inference (SEI) is widely used across neuroimaging modalities to study brain-
phenotype associations that inform our understanding of disease. Recent studies have …