Melanoma is the sixth most frequent malignancy. It represents 1.7% of all cancer cases
worldwide. Many risk factors are associated with melanoma including ultraviolet radiation …

CCR2 is predominantly expressed by monocytes/macrophages with strong proinflammatory
functions, prompting the development of CCR2 antagonists to dampen unwanted immune …

Chemokines are chemotactic cytokines that regulate the migration of immune cells.
Chemokines function as cues for the coordinated recruitment of immune cells into and out of …

Therapy resistance can arise within tumor cells because of genetic or phenotypic changes
(intrinsic resistance), or it can be the result of an interaction with the tumor microenvironment …

Melanoma treatment with the BRAF V600E inhibitor vemurafenib provides therapeutic
benefits but the common emergence of drug resistance remains a challenge. We generated …

Opinion statement Melanoma is caused by a variety of somatic mutations, and among these
mutations, BRAF mutation occurs most frequently and has routinely been evaluated as a …

Melanoma is one of the most aggressive and progressive skin cancers. It develops from
normal pigment-producing cells known as melanocytes, so it is important to know the …

Melanoma is a most dangerous and deadly type of skin cancer, and considered intrinsically
resistant to both radiotherapy and chemotherapy. It has become a major public health …

Non-coding RNAs (ncRNAs) have been implicated in most cellular functions. The disruption
of their function through somatic mutations, genomic imprinting, transcriptional and post …

MicroRNAs (miRNAs) are small and highly conserved non‐coding RNAs that silence target
mRNAs, and compelling evidence suggests that they play an essential role in the …