Abstract RNA polymerase II (RNA Pol II) speed or elongation rate, ie, the number of
nucleotides synthesized per unit of time, is a major determinant of transcriptome …

Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene
expression. The identification of the actual splice sites and the proper removal of introns are …

Physiological homeostasis becomes compromised during ageing, as a result of impairment
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …

Pre-mRNA processing steps are tightly coordinated with transcription in many organisms. To
determine how co-transcriptional splicing is integrated with transcription elongation and 3 …

Most RNA processing occurs co-transcriptionally. We interrogated nascent pol II transcripts
by chemical and enzymatic probing and determined how the" nascent RNA structureome" …

Transcription of eukaryotic genes by RNA polymerase II (Pol II) yields RNA precursors
containing introns that must be spliced out and the flanking exons ligated together. Splicing …

The production of ribosomes is an energy-intensive process owing to the intricacy of these
massive macromolecular machines. Each human ribosome contains 80 ribosomal proteins …

Abstract DDX5 and DDX17 are DEAD-box RNA helicase paralogs which regulate several
aspects of gene expression, especially transcription and splicing, through incompletely …

RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …

How the noncoding genome affects cellular functions is a key biological question. A
particular challenge is to distinguish the effects of noncoding DNA elements from long …