Precise patterns of gene expression in metazoans are controlled by three classes of
regulatory elements: promoters, enhancers and boundary elements. During differentiation …

Chromosome structure in mammals is thought to regulate transcription by modulating three-
dimensional interactions between enhancers and promoters, notably through CTCF …

The past decade has seen a huge jump in the resolution and scale at which we can
interrogate the three-dimensional properties of the genome. This revealed different types of …

Histone-modifying systems play fundamental roles in gene regulation and the development
of multicellular organisms. Histone modifications that are enriched at gene regulatory …

The specificity of interactions between genomic regulatory elements and potential target
genes is influenced by the binding of insulator proteins such as CTCF, which can act as …

Topologically associating domain (TAD) boundaries are thought to partition the genome into
distinct regulatory territories. Anecdotal evidence suggests that their disruption may interfere …

Clodagh O'Shea will never forget the moment in early 2015 when she peered at the cell's
nucleus in a way no one had ever done before. Using a new technique to visualize three …