S phingolipids constitute a class of lipids defined by their eighteen carbon amino-alcohol
backbones which are synthesized in the ER from nonsphingolipid precursors. Modification …

Synaptic vesicle recycling is one of the best‐studied cellular pathways. Many of the proteins
involved are known, and their interactions are becoming increasingly clear. However, as for …

Protein traffic moving from the endoplasmic reticulum (ER) to the Golgi complex in
mammalian cells passes through the tubulovesicular membrane clusters of the ER-Golgi …

Glucosylceramide synthase (GCS), converting ceramide to glucosylceramide, catalyzes the
first reaction of ceramide glycosylation in sphingolipid metabolism. This glycosylation by …

Protein misfolding leads to the formation of aggregated proteins and protein inclusions,
which are associated with synaptic loss and neuronal death in neurodegenerative diseases …

The transport and sorting of lipids from the sites of their synthesis to their appropriate
destinations are fundamental for membrane biogenesis. In the synthesis of sphingolipids in …

Communication between compartments of the exocytic and endocytic pathways in
eukaryotic cells involves transport carriers—vesicles and tubules—that mediate the vectorial …

The COPII coat assembles on endoplasmic reticulum membranes to coordinate the
collection of secretory cargo with the formation of transport vesicles. During COPII assembly …

The supramolecular cargo procollagen is loaded into coat protein complex II (COPII)-coated
carriers at endoplasmic reticulum (ER) exit sites by the receptor molecule TANGO1/cTAGE5 …

Budding yeast Sec16 is a large peripheral endoplasmic reticulum (ER) membrane protein
that functions in generating COPII transport vesicles and in clustering COPII components at …