Traumatic brain injury (TBI) remains one of the most fatal and debilitating conditions in the
world. Current clinical management in severe TBI patients is mainly concerned with …

Septic-associated encephalopathy (SAE) is a key manifestation of sepsis, ranging from
delirium to coma and occurring in up to 70% of patients admitted to the ICU. SAE is …

Background The indications for intracranial pressure (ICP) monitoring in patients with acute
brain injury and the effects of ICP on patients' outcomes are uncertain. The aims of this study …

The rapidly expanding field of big data analytics has started to play a pivotal role in the
evolution of healthcare practices and research. It has provided tools to accumulate, manage …

Severe traumatic brain injury (TBI) is currently managed in the intensive care unit with a
combined medical–surgical approach. Treatment aims to prevent additional brain damage …

Background In patients with traumatic brain injury, hypothermia can reduce intracranial
hypertension. The benefit of hypothermia on functional outcome is unclear. Methods We …

For patients who survive the initial bleeding event of a ruptured brain aneurysm, delayed
cerebral ischemia (DCI) is one of the most important causes of mortality and poor …

Clinical decisions are more promising and evidence-based, hence, big data analytics to
assist clinical decision-making has been expressed for a variety of clinical fields. Due to the …

Abstract Purpose of Review Over the last years, the focus of clinical and animal research in
subarachnoid hemorrhage (SAH) shifted towards the early phase after the bleeding based …

Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal
transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable …