[HTML][HTML] Impact of heavy metals on the environment and human health: Novel therapeutic insights to counter the toxicity

S Mitra, AJ Chakraborty, AM Tareq, TB Emran… - Journal of King Saud …, 2022 - Elsevier
Heavy metals are well-known environmental pollutants owing to their toxicity, longevity in
the atmosphere, and ability to accumulate in the human body via bioaccumulation. The …

Exposure of metal toxicity in Alzheimer's disease: An extensive review

F Islam, S Shohag, S Akhter, MR Islam… - Frontiers in …, 2022 - frontiersin.org
Metals serve important roles in the human body, including the maintenance of cell structure
and the regulation of gene expression, the antioxidant response, and neurotransmission …

Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress

S Haider, L Liaquat, S Ahmad, Z Batool, RA Siddiqui… - Plos one, 2020 - journals.plos.org
Currently prescribed medications for the treatment of Alzheimer's disease (AD) that are
based on acetylcholinesterase inhibition only offer symptomatic relief but do not provide …

NLRP3 inflammasome mediated pyroptosis is involved in cadmium exposure-induced neuroinflammation through the IL-1β/IkB-α-NF-κB-NLRP3 feedback loop in …

J Cai, H Guan, X Jiao, J Yang, X Chen, H Zhang… - Toxicology, 2021 - Elsevier
NLRP3 inflammasome mediated pyroptosis is involved in cadmium exposure-induced
neuroinflammation through the IL-1β/IkB-α-NF-κB-NLRP3 feedback loop in swine …

The alleviative effects of quercetin on cadmium-induced necroptosis via inhibition ROS/iNOS/NF-κB pathway in the chicken brain

L Liu, Y Liu, X Cheng, X Qiao - Biological Trace Element Research, 2021 - Springer
Cadmium (Cd), a ubiquitous environmental pollutant, has neurotoxicity to humans and
animals. Quercetin (QE), the main component of flavonoids, has strong antioxidant and anti …

Melatonin ameliorates cadmium-induced affective and cognitive impairments and hippocampal oxidative stress in rat

M Lamtai, S Azirar, O Zghari, S Ouakki… - … Trace Element Research, 2021 - Springer
The present work aims to evaluate the effect of melatonin (Mel) on affective and cognitive
disorders induced by chronic exposure to Cadmium (Cd). Male and female Wistar rats …

Nano‐selenium alleviates cadmium‐induced neurotoxicity in cerebrum via inhibiting gap junction protein connexin 43 phosphorylation

YR Xu, M Talukder, CX Li, YX Zhao… - Environmental …, 2024 - Wiley Online Library
Cadmium (Cd) as a ubiquitous toxic heavy metal is reported to affect the nervous system.
Selenium (Se) has been shown to have antagonistic effects against heavy metal toxicity. In …

Metal mixtures are associated with increased anxiety during pregnancy

Y Levin-Schwartz, W Cowell, HHL Hsu, MB Enlow… - Environmental …, 2022 - Elsevier
Background Exposure to low-dose toxic metals in the environment is ubiquitous. Several
murine studies have shown metals induce anxiety-like behaviors, and mechanistic research …

Phenotypic aging mediates the association between blood cadmium and depression: a population-based study

Y Wu, Q Wu, R Pan, W Yi, Y Li, X Jin, Y Liang… - … Science and Pollution …, 2023 - Springer
Depression is a serious public health problem today, especially in middle-aged and older
adults. Although the etiology of the disease has not been fully elucidated, environmental …

Potentiation of the apoptotic signaling pathway in both the striatum and hippocampus and neurobehavioral impairment in rats exposed chronically to a low− dose of …

Z Chouit, D Djellal, S Haddad, M Hanfer… - … Science and Pollution …, 2021 - Springer
Cadmium (Cd) is a highly toxic heavy metal. It accumulates in biological tissues, especially
in fish which constitutes a first rank food for humans, particularly in the coastal areas. This …