Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …

Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous
findings indicate that epigenetic age could be altered in viral infection. However, the …

Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …

Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …

Poisoning from pesticides is a global public health problem and accounts for nearly 300,000
deaths worldwide every year. Exposure to pesticides is inevitable; there are different modes …

Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …

The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Telomere length (TL) is associated with several aging-related diseases. Here, we present a
DNA methylation estimator of TL (DNAmTL) based on 140 CpGs. Leukocyte DNAmTL is …