Tumor-associated macrophages (TAMs) have multiple potent functions in cancer and, thus,
represent important therapeutic targets. These diverse functions highlight the heterogenous …

Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …

The kinetics of the immune changes in COVID-19 across severity groups have not been
rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine …

Ageing is characterized by the development of persistent pro-inflammatory responses that
contribute to atherosclerosis, metabolic syndrome, cancer and frailty,–. The ageing brain is …

Metabolic rewiring underlies the effector functions of macrophages,–, but the mechanisms
involved remain incompletely defined. Here, using unbiased metabolomics and stable …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

INTRODUCTION In all eukaryotic cells, lipid droplets (LDs) store and supply essential lipids
to produce signaling molecules, membrane building blocks, and metabolic energy. The LD …

Although most patients recover from acute COVID-19, some experience postacute sequelae
of severe acute respiratory syndrome coronavirus 2 infection (PASC). One subgroup of …

The coronavirus-disease 2019 (COVID-19) was announced as a global pandemic by the
World Health Organization. Challenges arise concerning how to optimally support the …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …