Caveolae are submicroscopic, plasma membrane pits that are abundant in many
mammalian cell types. The past few years have seen a quantum leap in our understanding …

Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …

Background Human skeletal muscle is composed of three major fiber types, referred to as
type 1, 2A, and 2X fibers. This heterogeneous cellular composition complicates the …

When wounded, eukaryotic cells reseal in a few seconds. Ca 2+ influx induces exocytosis of
lysosomes, a process previously thought to promote repair by 'patching'wounds. New …

Mitsugumin 53 (MG53), a muscle-specific TRIM family protein, is an essential component of
the cell membrane repair machinery. Here, we examined the translational value of targeting …

Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience
plasma membrane damage from a multitude of stressors in the extra-and intra-cellular …

Abstract Mitsugumin 53 (MG53) negatively regulates skeletal myogenesis by targeting
insulin receptor substrate 1 (IRS-1). Here, we show that MG53 is an ubiquitin E3 ligase that …

Plasma membrane repair is a conserved cellular response mediating active resealing of
membrane disruptions to maintain homeostasis and prevent cell death and progression of …

Rapid repair of plasma membrane wounds is critical for cellular survival. Muscle fibers are
particularly susceptible to injury, and defective sarcolemma resealing causes muscular …

Dysfunction of caveolae is involved in human muscle disease, although the underlying
molecular mechanisms remain unclear. In this paper, we have functionally characterized …