Assessing anhedonia in depression: Potentials and pitfalls
SJ Rizvi, DA Pizzagalli, BA Sproule… - … & Biobehavioral Reviews, 2016 - Elsevier
The resurgence of interest in anhedonia within major depression has been fuelled by
clinical trials demonstrating its utility in predicting antidepressant response as well as recent …
clinical trials demonstrating its utility in predicting antidepressant response as well as recent …
Sucrose preference test as a measure of anhedonic behavior in a chronic unpredictable mild stress model of depression: outstanding issues
DD Markov - Brain Sciences, 2022 - mdpi.com
Despite numerous studies on the neurobiology of depression, the etiological and
pathophysiological mechanisms of this disorder remain poorly understood. A large number …
pathophysiological mechanisms of this disorder remain poorly understood. A large number …
Making sense of rodent models of anhedonia
S Scheggi, MG De Montis… - International Journal of …, 2018 - academic.oup.com
A markedly reduced interest or pleasure in activities previously considered pleasurable is a
main symptom in mood disorder and psychosis and is often present in other psychiatric …
main symptom in mood disorder and psychosis and is often present in other psychiatric …
Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives
Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …
and has become a widely used model in the search for antidepressant drugs for major …
Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS
P Willner - Neuropsychobiology, 2005 - karger.com
The chronic mild stress (CMS) model of depression has high validity but has in the past
been criticized for being difficult to replicate. However, a large number of recent publications …
been criticized for being difficult to replicate. However, a large number of recent publications …
In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice
JF Cryan, C Mombereau - Molecular psychiatry, 2004 - nature.com
The ability to modify mice genetically has been one of the major breakthroughs in modern
medical science affecting every discipline including psychiatry. It is hoped that the …
medical science affecting every discipline including psychiatry. It is hoped that the …
Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration
T Strekalova, R Spanagel, D Bartsch… - …, 2004 - nature.com
In order to develop a model for a depression-like syndrome in mice, we subjected male
C57BL/6 mice to a 4-week-long chronic stress procedure, consisting of rat exposure …
C57BL/6 mice to a 4-week-long chronic stress procedure, consisting of rat exposure …
Behavioural characterisation of chronic unpredictable stress based on ethologically relevant paradigms in rats
The chronic unpredictable stress (CUS) paradigm is extensively used in preclinical
research. However, CUS exhibits translational inconsistencies, some of them resulting from …
research. However, CUS exhibits translational inconsistencies, some of them resulting from …
Clostridium butyricum Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior in Mice via the Gut-Brain Axis
J Sun, F Wang, X Hu, C Yang, H Xu… - Journal of Agricultural …, 2018 - ACS Publications
Abnormal gut microbiome has been associated with depression. The mechanism of
probiotics against depression remains unclear. This study aimed to determine whether …
probiotics against depression remains unclear. This study aimed to determine whether …
Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions
J Grønli, R Murison, E Fiske, B Bjorvatn, E Sørensen… - Physiology & …, 2005 - Elsevier
Many symptoms of human depressive disorders are also observed in animals after exposure
to unpredictable stressors. The chronic mild stress (CMS) paradigm was developed in order …
to unpredictable stressors. The chronic mild stress (CMS) paradigm was developed in order …