Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

JD Martin, H Cabral, T Stylianopoulos… - Nature reviews Clinical …, 2020 - nature.com
Multiple nanotherapeutics have been approved for patients with cancer, but their effects on
survival have been modest and, in some examples, less than those of other approved …

Materials engineering strategies for cancer vaccine adjuvant development

X Zhang, B Yang, Q Ni, X Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Cancer vaccines have emerged as a powerful new tool for cancer immunotherapy.
Adjuvants are vaccine ingredients that enhance the strength, velocity, and duration of the …

[HTML][HTML] Impact of lipid nanoparticle size on mRNA vaccine immunogenicity

KJ Hassett, J Higgins, A Woods, B Levy, Y Xia… - Journal of Controlled …, 2021 - Elsevier
Lipid nanoparticles (LNP) are effective delivery vehicles for messenger RNA (mRNA) and
have shown promise for vaccine applications. Yet there are no published reports detailing …

Modulation of immune responses by particle size and shape

MV Baranov, M Kumar, S Sacanna… - Frontiers in …, 2021 - frontiersin.org
The immune system has to cope with a wide range of irregularly shaped pathogens that can
actively move (eg, by flagella) and also dynamically remodel their shape (eg, transition from …

Biocompatibility, biodegradation and biomedical applications of poly (lactic acid)/poly (lactic-co-glycolic acid) micro and nanoparticles

EM Elmowafy, M Tiboni, ME Soliman - Journal of Pharmaceutical …, 2019 - Springer
Background Poly (lactic acid)(PLA) and poly (lactic-co-glycolic acid)(PLGA) are among the
well-documented FDA-approved polymers used for the preparation of safe and effective …

Polymeric nanoparticle vaccines to combat emerging and pandemic threats

D Wibowo, SHT Jorritsma, ZJ Gonzaga, B Evert… - Biomaterials, 2021 - Elsevier
Subunit vaccines are more advantageous than live attenuated vaccines in terms of safety
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …

[HTML][HTML] Nanoparticle vaccines

L Zhao, A Seth, N Wibowo, CX Zhao, N Mitter, C Yu… - Vaccine, 2014 - Elsevier
Nanotechnology increasingly plays a significant role in vaccine development. As vaccine
development orientates toward less immunogenic “minimalist” compositions, formulations …

[HTML][HTML] Nanovaccines: a game changing approach in the fight against infectious diseases

MAH Abusalah, H Chopra, A Sharma… - Biomedicine & …, 2023 - Elsevier
The field of nanotechnology has revolutionised global attempts to prevent, treat, and
eradicate infectious diseases in the foreseen future. Nanovaccines have proven to be a …

Shape and size-dependent immune response to antigen-carrying nanoparticles

S Kumar, AC Anselmo, A Banerjee… - Journal of Controlled …, 2015 - Elsevier
The immune system has evolved to recognize and respond to a wide variety of pathogens
and produce distinct immune responses against diverse pathogenic structures. Despite …

Orchestrating immune responses: How size, shape and rigidity affect the immunogenicity of particulate vaccines

N Benne, J van Duijn, J Kuiper, W Jiskoot… - Journal of Controlled …, 2016 - Elsevier
Particulate carrier systems are promising drug delivery vehicles for subunit vaccination as
they can enhance and direct the type of T cell response. In order to develop vaccines with …