Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges
Multiple nanotherapeutics have been approved for patients with cancer, but their effects on
survival have been modest and, in some examples, less than those of other approved …
survival have been modest and, in some examples, less than those of other approved …
Materials engineering strategies for cancer vaccine adjuvant development
Cancer vaccines have emerged as a powerful new tool for cancer immunotherapy.
Adjuvants are vaccine ingredients that enhance the strength, velocity, and duration of the …
Adjuvants are vaccine ingredients that enhance the strength, velocity, and duration of the …
[HTML][HTML] Impact of lipid nanoparticle size on mRNA vaccine immunogenicity
KJ Hassett, J Higgins, A Woods, B Levy, Y Xia… - Journal of Controlled …, 2021 - Elsevier
Lipid nanoparticles (LNP) are effective delivery vehicles for messenger RNA (mRNA) and
have shown promise for vaccine applications. Yet there are no published reports detailing …
have shown promise for vaccine applications. Yet there are no published reports detailing …
Modulation of immune responses by particle size and shape
The immune system has to cope with a wide range of irregularly shaped pathogens that can
actively move (eg, by flagella) and also dynamically remodel their shape (eg, transition from …
actively move (eg, by flagella) and also dynamically remodel their shape (eg, transition from …
Biocompatibility, biodegradation and biomedical applications of poly (lactic acid)/poly (lactic-co-glycolic acid) micro and nanoparticles
Background Poly (lactic acid)(PLA) and poly (lactic-co-glycolic acid)(PLGA) are among the
well-documented FDA-approved polymers used for the preparation of safe and effective …
well-documented FDA-approved polymers used for the preparation of safe and effective …
Polymeric nanoparticle vaccines to combat emerging and pandemic threats
D Wibowo, SHT Jorritsma, ZJ Gonzaga, B Evert… - Biomaterials, 2021 - Elsevier
Subunit vaccines are more advantageous than live attenuated vaccines in terms of safety
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …
[HTML][HTML] Nanoparticle vaccines
Nanotechnology increasingly plays a significant role in vaccine development. As vaccine
development orientates toward less immunogenic “minimalist” compositions, formulations …
development orientates toward less immunogenic “minimalist” compositions, formulations …
[HTML][HTML] Nanovaccines: a game changing approach in the fight against infectious diseases
The field of nanotechnology has revolutionised global attempts to prevent, treat, and
eradicate infectious diseases in the foreseen future. Nanovaccines have proven to be a …
eradicate infectious diseases in the foreseen future. Nanovaccines have proven to be a …
Shape and size-dependent immune response to antigen-carrying nanoparticles
S Kumar, AC Anselmo, A Banerjee… - Journal of Controlled …, 2015 - Elsevier
The immune system has evolved to recognize and respond to a wide variety of pathogens
and produce distinct immune responses against diverse pathogenic structures. Despite …
and produce distinct immune responses against diverse pathogenic structures. Despite …
Orchestrating immune responses: How size, shape and rigidity affect the immunogenicity of particulate vaccines
Particulate carrier systems are promising drug delivery vehicles for subunit vaccination as
they can enhance and direct the type of T cell response. In order to develop vaccines with …
they can enhance and direct the type of T cell response. In order to develop vaccines with …