Despite the promising advances in novel cancer therapy such as immune checkpoint
inhibitors (ICIs), limitations including therapeutic resistance and toxicity remain. In recent …

With the advent of next-generation sequencing, we have an unprecedented ability to study
tumor and host genomes as well as those of the vast array of microorganisms that exist …

Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Background: Several studies suggested an important role of the gut microbiota in the
pathophysiology of neurological disorders, implying that alteration of the gut microbiota …

Accumulating evidence supports not only the functional role of the gut microbiome in cancer
development and progression but also its role in defining the efficacy and toxicity of …

Although novel therapies, including immunotherapy, have dramatically improved outcomes
for many patients with cancer, overall outcomes are heterogeneous and existing biomarkers …

The relationship between gut microbiota and neurological diseases, including chronic pain,
has received increasing attention. The gut microbiome is a crucial modulator of visceral …

The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Cancer is a major health burden worldwide, and despite continuous advances in medical
therapies, resistance to standard drugs and adverse effects still represent an important …

Sensory neurons are activated by physical and chemical stimuli, eliciting sensations such as
temperature, touch, pain, and itch. From an evolutionary perspective, sensing danger is …