Many drugs, or their antecedents, were discovered through observation of their effects on
normal or disease physiology. For the past generation, this phenotypic drug discovery …

Animal models have historically played a critical role in the exploration and characterization
of disease pathophysiology, target identification, and in the in vivo evaluation of novel …

To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's
disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue …

Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder
that manifests with personality changes, movement disorders, and cognitive decline. It is …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …

Neurodegeneration in the brains of Huntington's disease patients is accompanied by
widespread changes in gene regulatory networks. Recent studies have found that these …

Huntington disease (HD) is an autosomal dominant inherited neurodegenerative disease
characterized by progressive motor, behavioral, and cognitive decline, resulting in death …

We have previously shown that exon 1 of the huntingtin gene does not always splice to exon
2 resulting in the production of a small polyadenylated mRNA (HTTexon1) that encodes the …

Neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD),
amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and spinocerebellar ataxias …