Background: Melatonin synchronizes central but also peripheral oscillators (fetal adrenal
gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of …

Many of melatonin's actions are mediated through interaction with the G-protein coupled
membrane bound melatonin receptors type 1 and type 2 (MT1 and MT2, respectively) or …

Background The timing of puberty in girls is occurring at an increasingly early age. While a
positive family history is recognised as a predisposing factor for early or precocious puberty …

Antioxidant enzymes form the first line of defense against free radicals in organisms. Their
regulation depends mainly on the oxidant status of the cell, given that oxidants are their …

Background Melatonin is widely available either on prescription for the treatment of sleep
disorders or as an over-the-counter dietary supplement. Melatonin has also recently been …

Melatonin was found to be a potent free radical scavenger in 1993. Since then over 800
publications have directly or indirectly confirmed this observation. Melatonin scavenges a …

Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity
occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including …

We investigated the relationship between oxidative stress and poor oocyte quality and
whether the antioxidant melatonin improves oocyte quality. Follicular fluid was sampled at …

Hemodynamic shear stress, the blood flow-generated frictional force acting on the vascular
endothelial cells, is essential for endothelial homeostasis under normal physiological …

Melatonin, through its different receptors, has pleiotropic functions in mammalian brain.
Melatonin is secreted mainly by the pineal gland and exerts its effects via receptor-mediated …