Folding dynamics of polymorphic G‐quadruplex structures

JT Grün, H Schwalbe - Biopolymers, 2022 - Wiley Online Library
Abstract G‐quadruplexes (G4), found in numerous places within the human genome, are
involved in essential processes of cell regulation. Chromosomal DNA G4s are involved for …

Detection of genomic G-quadruplexes in living cells using a small artificial protein

K Zheng, J Zhang, Y He, J Gong, C Wen… - Nucleic acids …, 2020 - academic.oup.com
Abstract G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated
in essential physiological and pathological processes and serve as important drug targets …

[HTML][HTML] Structural motifs and intramolecular interactions in non-canonical G-quadruplexes

J Jana, S Mohr, YM Vianney, K Weisz - RSC Chemical Biology, 2021 - pubs.rsc.org
Guanine (G)-rich DNA or RNA sequences can assemble or intramolecularly fold into G-
quadruplexes formed through the stacking of planar G· G· G· G tetrads in the presence of …

Comprehensive analysis of intramolecular G-quadruplex structures: furthering the understanding of their formalism

M Farag, L Mouawad - Nucleic Acids Research, 2024 - academic.oup.com
Abstract G-quadruplexes (G4) are helical structures found in guanine-rich DNA or RNA
sequences. Generally, their formalism is based on a few dozen structures, which can …

Intra-locked G-quadruplex structures formed by irregular DNA G-rich motifs

A Maity, FR Winnerdy, WD Chang, G Chen… - Nucleic Acids …, 2020 - academic.oup.com
G-rich DNA sequences with tracts of three or more continuous guanines (G≥ 3) are known
to have high propensity to adopt stable G-quadruplex (G4) structures. Bioinformatic analyses …

The ion-dipole correction of the 3DRISM solvation model to accurately compute water distributions around negatively charged biomolecules

S Cao, Y Qiu, IC Unarta, EC Goonetilleke… - The Journal of …, 2022 - ACS Publications
The 3D reference interaction site model (3DRISM) provides an efficient grid-based solvation
model to compute the structural and thermodynamic properties of biomolecules in aqueous …

Quadruplex–Duplex Junction: A High‐Affinity Binding Site for Indoloquinoline Ligands

YM Vianney, P Preckwinkel, S Mohr… - Chemistry–A European …, 2020 - Wiley Online Library
A parallel quadruplex derived from the Myc promoter sequence was extended by a stem‐
loop duplex at either its 5′‐or 3′‐terminus to mimic a quadruplex–duplex (Q–D) junction …

Locked nucleic acid building blocks as versatile tools for advanced G-quadruplex design

L Haase, K Weisz - Nucleic Acids Research, 2020 - academic.oup.com
A hybrid-type G-quadruplex is modified with LNA (locked nucleic acid) and 2′-F-
riboguanosine in various combinations at the two syn positions of its third antiparallel G …

Quadruplex structure and diversity

FR Winnerdy, AT Phan - Annual Reports in Medicinal Chemistry, 2020 - Elsevier
G-quadruplex topological diversity is reviewed based on the structural elements: G-tetrads,
G-columns and loops. Each of the structural elements has its own individual and relational …

Insight into formation propensity of pseudocircular DNA G-hairpins

ML Živković, M Gajarský, K Beková… - Nucleic Acids …, 2021 - academic.oup.com
We recently showed that Saccharomyces cerevisiae telomeric DNA can fold into an
unprecedented pseudocircular G-hairpin (PGH) structure. However, the formation of PGHs …