Research conducted over the past several decades has revolutionized our understanding of
the role of the immune system in neural and psychological development and function across …

Increasing evidence from animal and human studies suggests that inflammation may be
involved in mood disorders. Sickness behavior and emotional changes induced by …

Depression onset peaks during adolescence and young adulthood. Current treatments are
only moderately effective, driving the search for novel pathophysiological mechanisms …

Depression is one of the global leading causes of disability, but treatments remain limited
and classical antidepressants were found to be ineffective in a substantial proportion of …

Chronic or persistent fatigue is a common, debilitating symptom of several diseases.
Persistent fatigue has been associated with low-grade inflammation in several models of …

Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward
motivation, and/or deficits in reward-related learning, is a common feature of depression …

A wealth of evidence has implicated inflammation in the development of depression. Yet, the
heterogeneous nature of depression has impeded efforts to understand, prevent, and treat …

Highlights•Discrete processes underlying anhedonia can be computationally
operationalized.•Approaches include models of reinforcement learning and effort-based …

Fatigue is a highly disabling symptom in various medical conditions. While inflammation has
been suggested as a potential contributor to the development of fatigue, underlying …

Throughout human evolution, infectious diseases have been a primary cause of death.
Detection of subtle cues indicating sickness and avoidance of sick conspecifics would …