Targeting fatty acid metabolism in glioblastoma
J Miska, NS Chandel - The Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
Glioblastoma (GBM) is a primary tumor of the brain defined by its uniform lethality and
resistance to conventional therapies. There have been considerable efforts to untangle the …
resistance to conventional therapies. There have been considerable efforts to untangle the …
The use of ketogenic diets in cancer patients: a systematic review
M Römer, J Dörfler, J Huebner - Clinical and experimental medicine, 2021 - Springer
Ketogenic diets are a widely known, yet controversial treatment for cancer patients. In this
review, we summarize the clinical evidence for anti-tumor effects, as well as the effects on …
review, we summarize the clinical evidence for anti-tumor effects, as well as the effects on …
Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs
P Saavedra-García, M Roman-Trufero… - Proceedings of the …, 2021 - National Acad Sciences
Cancer cells can survive chemotherapy-induced stress, but how they recover from it is not
known. Using a temporal multiomics approach, we delineate the global mechanisms of …
known. Using a temporal multiomics approach, we delineate the global mechanisms of …
Integrative rare disease biomedical profile based network supporting drug repurposing or repositioning, a case study of glioblastoma
Background Glioblastoma (GBM) is the most aggressive and common malignant primary
brain tumor; however, treatment remains a significant challenge. This study aims to identify …
brain tumor; however, treatment remains a significant challenge. This study aims to identify …
Cellular redox imbalance on the crossroad between mitochondrial dysfunction, senescence, and proliferation
Recent studies demonstrate that redox imbalance of NAD+/NADH and NADP+/NADPH pairs
due to impaired respiration may trigger two “hidden” metabolic pathways on the crossroad …
due to impaired respiration may trigger two “hidden” metabolic pathways on the crossroad …
The efficacy of an unrestricted cycling ketogenic diet in preclinical models of IDH wild-type and IDH mutant glioma
Infiltrative gliomas are the most common neoplasms arising in the brain, and remain largely
incurable despite decades of research. A subset of these gliomas contains mutations in …
incurable despite decades of research. A subset of these gliomas contains mutations in …
[HTML][HTML] Integrative Rare Disease Biomedical Profile based Network Supporting Drug Repurposing, a case study of Glioblastoma
Background Glioblastoma (GBM) is the most aggressive and common malignant primary
brain tumor; however, treatment remains a significant challenge. This study aims to identify …
brain tumor; however, treatment remains a significant challenge. This study aims to identify …
[HTML][HTML] Targeting super-enhancers reprograms glioblastoma central carbon metabolism
TTT Nguyen, MA Westhoff, G Karpel-Massler… - Oncotarget, 2021 - ncbi.nlm.nih.gov
The concept that tumor cells demand a distinct form of metabolism was appreciated almost a
century ago when the German biochemist Otto Warburg realized that tumor cells heavily …
century ago when the German biochemist Otto Warburg realized that tumor cells heavily …
[图书][B] Epigenome and the lipidome rewiring for targeting IDH-mutant-gliomas
L Elahi - 2023 - search.proquest.com
Missense mutation in the gene isocitrate dehydrogenase (IDH) rewires the metabolic and
chromatin landscape of IDH mutant (MT) gliomas making them distinct from IDH wildtype …
chromatin landscape of IDH mutant (MT) gliomas making them distinct from IDH wildtype …
The efficacy of a ketogenic diet in preclinical models of IDH wild-type and IDH mutant glioma
Infiltrative gliomas are the most common neoplasms arising in the brain, and remain largely
incurable despite decades of research. A subset of these gliomas contains mutations in …
incurable despite decades of research. A subset of these gliomas contains mutations in …