Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most
important contributor from this subfamily to drug metabolism. Polymorphisms resulting in …

Type 2 diabetes has rapidly emerged as a global health crisis. Because population-level
genetic changes take many generations to occur, this epidemic is almost certainly primarily …

With rapidly increasing prevalence, diabetes has become one of the major causes of
mortality worldwide. According to the latest studies, genetic information makes substantial …

OBJECTIVE We performed a systematic review to identify which genetic variants predict
response to diabetes medications. RESEARCH DESIGN AND METHODS We performed a …

Background Large scale association studies have found a significant association between
type 2 diabetes mellitus (T2DM) and transcription factor 7-like 2 (TCF7L2) polymorphism …

Diabetes mellitus (DM) is a glucose metabolism disorder characterized by chronic
hyperglycemia resulting from a deficit of insulin production and/or action. DM affects more …

Pharmacogenomics is emerging as a popular type of study for human genetics in recent
years. This is primarily due to the many success stories and high potential for translation to …

Epigenetics has major relevance to all disease processes; cardiovascular (CV) disease and
its related conditions are no exception. Epigenetics is defined as the study of heritable …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by
overweight/obesity, and the presence of type 2 diabetes mellitus is the most important …