Background: Chronic axial spinal pain is one of the major causes of significant disability and
health care costs, with facet joints as one of the proven causes of pain. Objective: To provide …

Background: Several cell-based therapies have been proposed in recent years the
management of low back pain, including the injection of medicinal signaling cells or …

Objectives To use data from the Global Burden of Diseases, Injuries, and Risk Factors Study
2019 (GBD 2019) to estimate mortality and disability trends for the population aged≥ 70 …

Importance US health care spending has continued to increase and now accounts for 18%
of the US economy, although little is known about how spending on each health condition …

Importance Health care spending in the United States is a major concern and is higher than
in other high-income countries, but there is little evidence that efforts to reform US health …

Background: Cost-effectiveness analysis is an important tool for informing treatment
coverage and pricing decisions, yet no consensus exists about what threshold for the …

Background: Opioid use, abuse, and adverse consequences, including death, have
escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse …

Importance Medical debt is an increasing concern in the US, yet there is limited
understanding of the amount and distribution of medical debt, and its association with health …

A 2003 article titled “It's the Prices, Stupid,” and coauthored by the three of us and the
recently deceased Uwe Reinhardt found that the sizable differences in health spending …

Background: Spending on cardiovascular disease and cardiovascular risk factors
(cardiovascular spending) accounts for a significant portion of overall US health care …