Suicide and suicide risk

G Turecki, DA Brent, D Gunnell, RC O'Connor… - Nature reviews Disease …, 2019 - nature.com
Although recent years have seen large decreases in the overall global rate of suicide
fatalities, this trend is not reflected everywhere. Suicide and suicidal behaviour continue to …

Neuropathology of suicide: recent findings and future directions

PE Lutz, N Mechawar, G Turecki - Molecular psychiatry, 2017 - nature.com
Suicide is a major public health concern and a leading cause of death in most societies.
Suicidal behaviour is complex and heterogeneous, likely resulting from several causes. It …

Genetic association studies of suicidal behavior: a review of the past 10 years, progress, limitations, and future directions

B Mirkovic, C Laurent, MA Podlipski, T Frebourg… - Frontiers in …, 2016 - frontiersin.org
Suicidal behaviors (SBs), which range from suicidal ideation to suicide attempts and
completed suicide, represent a fatal dimension of mental ill-health. The involvement of …

The epigenetic impacts of social stress: how does social adversity become biologically embedded?

VT Cunliffe - Epigenomics, 2016 - Taylor & Francis
Epigenetic mechanisms are implicated in the processes through which social stressors
erode health in humans and other animals. Here I review progress in elucidating the …

Exploiting circulating MicroRNAs as biomarkers in psychiatric disorders

B Roy, Y Yoshino, L Allen, K Prall, G Schell… - Molecular diagnosis & …, 2020 - Springer
Non-invasive peripheral biomarkers play a significant role in both disease diagnosis and
progression. In the past few years, microRNA (miRNA) expression changes in circulating …

Can epigenetics shine a light on the biological pathways underlying major mental disorders?

L Alameda, G Trotta, H Quigley, V Rodriguez… - Psychological …, 2022 - cambridge.org
A significant proportion of the global burden of disease can be attributed to mental illness.
Despite important advances in identifying risk factors for mental health conditions, the …

Understanding suicide risk within the Research Domain Criteria (RDoC) framework: Insights, challenges, and future research considerations

CR Glenn, CB Cha, EM Kleiman… - Clinical psychological …, 2017 - journals.sagepub.com
Suicide is a leading cause of death worldwide. Prior research has focused primarily on
sociodemographic and psychiatric risk factors with little improvement in the prediction or …

Epigenetic alterations associated with childhood trauma and adult mental health outcomes: A systematic review

J Nöthling, S Malan-Müller, N Abrahams… - The World Journal of …, 2020 - Taylor & Francis
Objectives: Multiple, chronic and repeated trauma exposure in childhood is associated with
adverse mental health outcomes in adulthood. In this paper we synthesise the literature on …

New translational perspectives for blood-based biomarkers of PTSD: from glucocorticoid to immune mediators of stress susceptibility

NP Daskalakis, H Cohen, CM Nievergelt… - Experimental …, 2016 - Elsevier
Although biological systems have evolved to promote stress-resilience, there is variation in
stress-responses. Understanding the biological basis of such individual differences has …

Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder

C Snijders, AX Maihofer, A Ratanatharathorn… - Clinical …, 2020 - Springer
Background Epigenetic mechanisms have been suggested to play a role in the development
of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data …