Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Worldwide, diarrhea claims several million lives annually, mostly those of infants. Poverty,
crowding, and contaminated water supplies all contribute. Almost all of these deaths could …

NHE3 is one of five plasma membrane Na+/H+ exchangers 1, 2, 3 and is encoded by the
mouse gene Slc9a3. It is expressed on apical membranes of renal proximal tubule 4, 5 and …

The colonic epithelium has both absorptive and secretory functions. The transport is
characterized by a net absorption of NaCl, short-chain fatty acids (SCFA), and water …

This brief review of the human Na/H exchanger gene family introduces a new classification
with three subgroups to the SLC9 gene family. Progress in the structure and function of this …

Sodium/proton antiporters or exchangers (NHE) are integral membrane proteins present in
most, if not all, living organisms. In mammals, these transporters chiefly catalyze the …

The Na+/H+ exchanger (NHE) is involved in intracellular pH homeostasis of many
mammalian cell types. To date seven NHE isoforms (NHE1–NHE7) have been identified …

▪ Abstract Chloride secretion is the major determinant of mucosal hydration thoughout the
gastrointestinal tract, and chloride transport is also pivotal in the regulation of fluid secretion …

Tubular reabsorption of filtered sodium is quantitatively the main contribution of kidneys to
salt and water homeostasis. The transcellular reabsorption of sodium proceeds by a two …

The mechanisms underlying acid–base transfers across the branchial epithelium of fishes
have been studied for more than 70 years. These animals are able to compensate for …