A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Importance Stem cell therapy is a promising treatment strategy for patients with heart failure,
which accounts for more than 10% of deaths in the United States annually. Despite more …

1.1. Methodology and Evidence Review The recommendations listed in this document are,
whenever possible, evidence based. The current document constitutes a full revision and …

Aims CONCERT‐HF is an NHLBI‐sponsored, double‐blind, placebo‐controlled, Phase II
trial designed to determine whether treatment with autologous bone marrow‐derived …

Summary Background Cardiosphere-derived cells (CDCs) reduce scarring after myocardial
infarction, increase viable myocardium, and boost cardiac function in preclinical models. We …

Objectives: This study sought to evaluate the feasibility and safety of autologous bone
marrow–derived and cardiogenically oriented mesenchymal stem cell therapy and to probe …

Rationale: Although accumulating data support the efficacy of intramyocardial cell-based
therapy to improve left ventricular (LV) function in patients with chronic ischemic …

Rationale: The meta-Analysis of Cell-based CaRdiac study is the first prospectively declared
collaborative multinational database, including individual data of patients with ischemic …

Despite improvements in modern cardiovascular therapy, the morbidity and mortality of
ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and …

Context Previous studies using autologous bone marrow mononuclear cells (BMCs) in
patients with ischemic cardiomyopathy have demonstrated safety and suggested efficacy …