Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

MicroRNAs (miRNAs) are a class of short, non-coding RNAs that function post-
transcriptionally to regulate gene expression by binding to particular mRNA targets and …

We integrated ubiquity, mass and lifespan of all major cell types to achieve a comprehensive
quantitative description of cellular turnover. We found a total cellular mass turnover of 80±20 …

Microglia play a critical role in brain homeostasis and disease progression. In
neurodegenerative conditions, microglia acquire the neurodegenerative phenotype (MGnD) …

Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

INTRODUCTION MicroRNAs (miRNAs) are short RNAs that guide repression of mRNA
targets. Each miRNA associates with an Argonaute (AGO) protein to form a complex in …

MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

Alzheimer's disease (AD) is the most common neurodegenerative disease, with cognitive
decline as the primary clinical feature. According to epidemiological statistics, 50 million …

The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in
1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was …

MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary
target mRNAs and repress their expression. Precursor miRNA molecules undergo nuclear …