Aminolevulinic acid (5-ALA)-mediated fluorescence does not effectively depict low grade
gliomas (LGG) or the infiltrative tumor portion of high-grade gliomas (HGG). While …

Gliomas are diffuse and hard to cure brain tumors. A major reason for their aggressive
behavior is their property to infiltrate the brain. The gross appearance of the infiltrative …

The review begins with an overview of the fundamental principles/physics underlying light,
fluorescence, and other light-matter interactions in biological tissues. It then focuses on 5 …

Advanced stage glioma is the most aggressive form of malignant brain tumors with a short
survival time. Real-time pathology assisted, or image guided surgical procedures that …

Gliomas are infiltrative brain tumors with a margin difficult to identify. 5-ALA induced PpIX
fluorescence measurements are a clinical standard, but expert-based classification models …

A key challenge of central nervous system tumor surgery is to discriminate between brain
regions infiltrated by tumor cells and surrounding healthy tissue. Although monitoring of …

Spectroscopy is a popular technique for identifying and quantifying fluorophores in
fluorescent materials. However, quantifying the fluorophore of interest can be challenging …

Introduction The intrinsic autofluorescence of biological tissues interferes with the detection
of fluorophores administered for fluorescence guidance, an emerging auxiliary technique in …

Current in vivo neuroimaging techniques provide limited field of view or spatial resolution
and often require exogenous contrast. These limitations prohibit detailed structural imaging …

Among all the tumors of the central nervous system (CNS), glioma are the most deadly and
the most malignant. Surgical resection is the standard therapeutic method to treat this type of …