Ovarian cancer is the deadliest gynecological cancer, leading to over 152,000 deaths each
year. A late diagnosis is the primary factor causing a poor prognosis of ovarian cancer and …

Importance Ovarian cancer is relatively rare but the fifth-leading cause of cancer mortality
among United States women. Objective To systematically review evidence on benefits and …

Over three decades have passed since the first report on the expression of CA125 by
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …

Context Screening for ovarian cancer with cancer antigen 125 (CA-125) and transvaginal
ultrasound has an unknown effect on mortality. Objective To evaluate the effect of screening …

Inherited loss-of-function mutations in BRCA1 and BRCA2 and other tumor suppressor
genes predispose to ovarian carcinomas, but the overall burden of disease due to inherited …

Recent morphologic, immunohistochemical, and molecular genetic studies have led to the
development of a new paradigm for the pathogenesis and origin of epithelial ovarian cancer …

Ovarian cancer is the most lethal gynecologic malignancy. Efforts at early detection and new
therapeutic approaches to reduce mortality have been largely unsuccessful, because the …

Papanicolaou (Pap) smears have revolutionized the management of patients with cervical
cancers by permitting the detection of early, surgically curable tumors and their precursors …

Extracellular vesicles (EVs) are messengers that carry information in the form of proteins,
lipids, and nucleic acids and are not only essential for intercellular communication but also …

Foreword This Journal feature begins with a case vignette highlighting a common clinical
problem. Evidence supporting various strategies is then presented, followed by a review of …