Background: Antimicrobial resistance represents a serious threat to human health across the
globe. The cost of bringing a new antibiotic from discovery to market is high and return on …

The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

The spatial organization of genes within plant genomes can drive evolution of specialized
metabolic pathways. Terpenoids are important specialized metabolites in plants with diverse …

Antibiotics are among the most often used medications in human healthcare and agriculture.
Overusing these substances can lead to complications such as increasing antibiotic …

The structural determination of natural products (NPs) can be arduous because of sample
heterogeneity. This often demands iterative purification processes and characterization of …

Antimicrobial resistance (AMR) has emerged as a global health crisis, necessitating the
search for innovative strategies to combat infectious diseases. The unique biodiversity of …

Drug resistance threatening humans may be linked with antimicrobial and anthelmintic
resistance in other species, especially among farm animals and, more in general, in the …

Over the past decades, antibiotic resistance has grown to a point where orthogonal
approaches to combating infections caused by resistant bacteria are needed. One such …

Methicillin-resistant Staphylococcus aureus (MRSA) poses a severe threat to public health
and safety. The discovery and development of novel anti-MRSA drugs with a new mode of …

Twelve new clerodane diterpenoids named callicarpanes A–L (1–12), together with eight
known compounds (13–20), were isolated from Callicarpa integerrima. Their structures were …