[HTML][HTML] Epstein–Barr virus and multiple sclerosis
SS Soldan, PM Lieberman - Nature Reviews Microbiology, 2023 - nature.com
Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …
established causal role in several cancers. Recent studies have provided compelling …
Harmonizing definitions for progression independent of relapse activity in multiple sclerosis: A systematic review
J Müller, A Cagol, J Lorscheider, C Tsagkas… - JAMA …, 2023 - jamanetwork.com
Importance Emerging evidence suggests that progression independent of relapse activity
(PIRA) is a substantial contributor to long-term disability accumulation in relapsing-remitting …
(PIRA) is a substantial contributor to long-term disability accumulation in relapsing-remitting …
Serum glial fibrillary acidic protein compared with neurofilament light chain as a biomarker for disease progression in multiple sclerosis
S Meier, EAJ Willemse, S Schaedelin… - JAMA …, 2023 - jamanetwork.com
Importance There is a lack of validated biomarkers for disability progression independent of
relapse activity (PIRA) in multiple sclerosis (MS). Objective To determine how serum glial …
relapse activity (PIRA) in multiple sclerosis (MS). Objective To determine how serum glial …
[HTML][HTML] A real-world clinical validation for AI-based MRI monitoring in multiple sclerosis
Modern management of MS targets No Evidence of Disease Activity (NEDA): no clinical
relapses, no magnetic resonance imaging (MRI) disease activity and no disability …
relapses, no magnetic resonance imaging (MRI) disease activity and no disability …
Neurofilament light chain elevation and disability progression in multiple sclerosis
A Abdelhak, P Benkert, S Schaedelin… - JAMA …, 2023 - jamanetwork.com
Importance Mechanisms contributing to disability accumulation in multiple sclerosis (MS) are
poorly understood. Blood neurofilament light chain (NfL) level, a marker of neuroaxonal …
poorly understood. Blood neurofilament light chain (NfL) level, a marker of neuroaxonal …
[HTML][HTML] Multiple sclerosis: role of meningeal lymphoid aggregates in progression independent of relapse activity
RM Ransohoff - Trends in Immunology, 2023 - cell.com
The emphasis on mechanisms driving multiple sclerosis (MS) symptomatic worsening
suggests that we move beyond categorical clinical classifiers such as relapsing–remitting …
suggests that we move beyond categorical clinical classifiers such as relapsing–remitting …
B cell depletion with anti-CD20 promotes neuroprotection in a BAFF-dependent manner in mice and humans
AA Wang, F Luessi, T Neziraj, E Pössnecker… - Science Translational …, 2024 - science.org
Anti-CD20 therapy to deplete B cells is highly efficacious in preventing new white matter
lesions in patients with relapsing-remitting multiple sclerosis (RRMS), but its protective …
lesions in patients with relapsing-remitting multiple sclerosis (RRMS), but its protective …
Toward identifying key mechanisms of progression in multiple sclerosis
L Husseini, A Geladaris, MS Weber - Trends in Neurosciences, 2024 - cell.com
A major therapeutic goal in the treatment of multiple sclerosis (MS) is to prevent the
accumulation of disability over an often decades-long disease course. Disability progression …
accumulation of disability over an often decades-long disease course. Disability progression …
Association of spinal cord atrophy and brain paramagnetic rim lesions with progression independent of relapse activity in people with MS
A Cagol, P Benkert, L Melie-Garcia, SA Schaedelin… - Neurology, 2024 - AAN Enterprises
Background and Objectives Progression independent of relapse activity (PIRA) is a crucial
determinant of overall disability accumulation in multiple sclerosis (MS). Accelerated brain …
determinant of overall disability accumulation in multiple sclerosis (MS). Accelerated brain …
Determinants and biomarkers of progression independent of relapses in multiple sclerosis
Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a
smoldering inflammatory activity is present from the earliest stages of the disease and …
smoldering inflammatory activity is present from the earliest stages of the disease and …