Communication between the brain and gut is not one-way, but a bidirectional highway
whereby reciprocal signals between the two organ systems are exchanged to coordinate …

The physiological consequences of stress often manifest in the gastrointestinal tract.
Traumatic or chronic stress is associated with widespread maladaptive changes throughout …

The intestine serves as an important digestive and the largest immune organ in the body.
Interleukin-6 (IL-6), an important mediator of various pathways, participates in the …

Background: Corticotropin-releasing factor (CRF) pathways coordinate behavioral,
endocrine, autonomic and visceral responses to stress. Convergent anatomical, molecular …

The corticotropin-releasing factor (CRF) signaling systems encompass CRF and the
structurally related peptide urocortin (Ucn) 1, 2, and 3 along with 2 G-protein coupled …

Key points Hyperactivity of the stress system and low‐grade immune activation characterize
the functional bowel disorder irritable bowel syndrome (IBS). These studies show that …

In June 2016, the National Institutes of Health hosted a workshop on functional bowel
disorders (FBDs), particularly irritable bowel syndrome, with the objective of elucidating …

Disordered signalling between the brain and the gut are generally accepted to underlie the
functional bowel disorder, irritable bowel syndrome (IBS). However, partly due to the lack of …

The aim of the present study was to examine the effect of a replacement diet with organic,
semi-whole-grain products derived from Triticum turgidum subsp. turanicum (ancient) wheat …

Disorders of gut-brain interaction (DGBI), formerly termed functional gastrointestinal
disorders (FGID), are highly prevalent although exact pathophysiological mechanisms …