Background Strong surveillance systems with wide geographic coverage are needed to
detect and respond to reports of antimalarial drug resistance on the African continent. We …

Background In a recent trial of intermittent preventive treatment in pregnancy (IPTp) in
Uganda, dihydroartemisinin-piperaquine (DP) was superior to sulfadoxine-pyrimethamine …

Background Over the last two decades, the scale-up of vector control and changes in the first-
line anti-malarial, from chloroquine (CQ) to sulfadoxine-pyrimethamine (SP) and then to …

Gametocytes are sexual stage malaria parasites responsible for transmission to mosquitoes.
Multiple gametocyte-producing clones may be present in natural infections, but the …

Population genetic diversity of Plasmodium falciparum antigenic loci is high despite large
bottlenecks in population size during the parasite life cycle. The prevalence of genetically …

Abstract Background In Southeast Asia, people are often coinfected with different species of
malaria (Plasmodium falciparum [Pf] and Plasmodium vivax [Pv]) as well as with multiple …

Genetic changes conferring drug resistance are generally believed to impose fitness costs to
pathogens in the absence of the drug. However, the fitness of resistant parasites against …

Interindividual and interpopulation differences may be used to guide and optimize disease
treatment based on genetics and this is referred to as pharmacogenetics or …

Artemisinin-based combination therapies (ACTs) are among the most important tools in our
arsenal to treat and control malaria. ACTs and other antimalarial drugs have contributed to …

Genetic changes conferring drug resistance are generally believed to impose fitness costs to
pathogens in the absence of the drug. However, the fitness of resistant parasites against …