[HTML][HTML] Recent advances in prostate cancer treatment and drug discovery

E Nevedomskaya, SJ Baumgart… - International journal of …, 2018 - mdpi.com
Novel drugs, drug sequences and combinations have improved the outcome of prostate
cancer in recent years. The latest approvals include abiraterone acetate, enzalutamide and …

[HTML][HTML] Underlying features of prostate cancer—statistics, risk factors, and emerging methods for its diagnosis

CV Berenguer, F Pereira, JS Câmara, JAM Pereira - Current Oncology, 2023 - mdpi.com
Prostate cancer (PCa) is the most frequently occurring type of malignant tumor and a leading
cause of oncological death in men. PCa is very heterogeneous in terms of grade …

[HTML][HTML] RetroPath2. 0: a retrosynthesis workflow for metabolic engineers

B Delépine, T Duigou, P Carbonell, JL Faulon - Metabolic engineering, 2018 - Elsevier
Synthetic biology applied to industrial biotechnology is transforming the way we produce
chemicals. However, despite advances in the scale and scope of metabolic engineering, the …

[HTML][HTML] Prostate cancer–specific PET radiotracers: A review on the clinical utility in recurrent disease

JD Evans, KR Jethwa, P Ost, S Williams… - Practical radiation …, 2018 - Elsevier
Prostate cancer–specific positron emission tomography (pcPET) has been shown to detect
sites of disease recurrence at serum prostate-specific antigen (PSA) levels that are lower …

[HTML][HTML] Advances and perspectives in prostate cancer biomarker discovery in the last 5 years through tissue and urine metabolomics

AR Lima, J Pinto, F Amaro, ML Bastos, M Carvalho… - Metabolites, 2021 - mdpi.com
Prostate cancer (PCa) is the second most diagnosed cancer in men worldwide. For its
screening, serum prostate specific antigen (PSA) test has been largely performed over the …

Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression

M Clos-Garcia, A Loizaga-Iriarte… - Journal of …, 2018 - Taylor & Francis
Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from
degradation. Thus, isolation and characterisation of urinary EVs could increase the …

Discovery and validation of clinical biomarkers of cancer: a review combining metabolomics and proteomics

A Srivastava, DJ Creek - Proteomics, 2019 - Wiley Online Library
Early detection and diagnosis of cancer can allow timely medical intervention, which greatly
improves chances of survival and enhances quality of life. Biomarkers play an important role …

[HTML][HTML] c-Myc antagonises the transcriptional activity of the androgen receptor in prostate cancer affecting key gene networks

SJ Barfeld, A Urbanucci, HM Itkonen, L Fazli… - …, 2017 - thelancet.com
Prostate cancer (PCa) is the most common non-cutaneous cancer in men. The androgen
receptor (AR), a ligand-activated transcription factor, constitutes the main drug target for …

The applications of metabolomics in the molecular diagnostics of cancer

PK Cheung, MH Ma, HF Tse, KF Yeung… - Expert review of …, 2019 - Taylor & Francis
Introduction: Metabolomics, the study of metabolites, is a promising research field for
cancers. The metabolic pathway in a tumor cell is different from a normal tissue cell. There …

[HTML][HTML] Volatilomics: an emerging and promising avenue for the detection of potential prostate cancer biomarkers

CV Berenguer, F Pereira, JAM Pereira, JS Câmara - Cancers, 2022 - mdpi.com
Simple Summary The lack of highly specific and sensitive biomarkers for the early detection
of prostate cancer (PCa) is a major barrier to its management. Volatilomics emerged as a …