[HTML][HTML] Recent advances in prostate cancer treatment and drug discovery
E Nevedomskaya, SJ Baumgart… - International journal of …, 2018 - mdpi.com
Novel drugs, drug sequences and combinations have improved the outcome of prostate
cancer in recent years. The latest approvals include abiraterone acetate, enzalutamide and …
cancer in recent years. The latest approvals include abiraterone acetate, enzalutamide and …
[HTML][HTML] Underlying features of prostate cancer—statistics, risk factors, and emerging methods for its diagnosis
Prostate cancer (PCa) is the most frequently occurring type of malignant tumor and a leading
cause of oncological death in men. PCa is very heterogeneous in terms of grade …
cause of oncological death in men. PCa is very heterogeneous in terms of grade …
[HTML][HTML] RetroPath2. 0: a retrosynthesis workflow for metabolic engineers
Synthetic biology applied to industrial biotechnology is transforming the way we produce
chemicals. However, despite advances in the scale and scope of metabolic engineering, the …
chemicals. However, despite advances in the scale and scope of metabolic engineering, the …
[HTML][HTML] Prostate cancer–specific PET radiotracers: A review on the clinical utility in recurrent disease
JD Evans, KR Jethwa, P Ost, S Williams… - Practical radiation …, 2018 - Elsevier
Prostate cancer–specific positron emission tomography (pcPET) has been shown to detect
sites of disease recurrence at serum prostate-specific antigen (PSA) levels that are lower …
sites of disease recurrence at serum prostate-specific antigen (PSA) levels that are lower …
[HTML][HTML] Advances and perspectives in prostate cancer biomarker discovery in the last 5 years through tissue and urine metabolomics
AR Lima, J Pinto, F Amaro, ML Bastos, M Carvalho… - Metabolites, 2021 - mdpi.com
Prostate cancer (PCa) is the second most diagnosed cancer in men worldwide. For its
screening, serum prostate specific antigen (PSA) test has been largely performed over the …
screening, serum prostate specific antigen (PSA) test has been largely performed over the …
Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression
M Clos-Garcia, A Loizaga-Iriarte… - Journal of …, 2018 - Taylor & Francis
Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from
degradation. Thus, isolation and characterisation of urinary EVs could increase the …
degradation. Thus, isolation and characterisation of urinary EVs could increase the …
Discovery and validation of clinical biomarkers of cancer: a review combining metabolomics and proteomics
A Srivastava, DJ Creek - Proteomics, 2019 - Wiley Online Library
Early detection and diagnosis of cancer can allow timely medical intervention, which greatly
improves chances of survival and enhances quality of life. Biomarkers play an important role …
improves chances of survival and enhances quality of life. Biomarkers play an important role …
[HTML][HTML] c-Myc antagonises the transcriptional activity of the androgen receptor in prostate cancer affecting key gene networks
SJ Barfeld, A Urbanucci, HM Itkonen, L Fazli… - …, 2017 - thelancet.com
Prostate cancer (PCa) is the most common non-cutaneous cancer in men. The androgen
receptor (AR), a ligand-activated transcription factor, constitutes the main drug target for …
receptor (AR), a ligand-activated transcription factor, constitutes the main drug target for …
The applications of metabolomics in the molecular diagnostics of cancer
PK Cheung, MH Ma, HF Tse, KF Yeung… - Expert review of …, 2019 - Taylor & Francis
Introduction: Metabolomics, the study of metabolites, is a promising research field for
cancers. The metabolic pathway in a tumor cell is different from a normal tissue cell. There …
cancers. The metabolic pathway in a tumor cell is different from a normal tissue cell. There …
[HTML][HTML] Volatilomics: an emerging and promising avenue for the detection of potential prostate cancer biomarkers
Simple Summary The lack of highly specific and sensitive biomarkers for the early detection
of prostate cancer (PCa) is a major barrier to its management. Volatilomics emerged as a …
of prostate cancer (PCa) is a major barrier to its management. Volatilomics emerged as a …