Metastasis is a complex process that requires the interaction between tumor cells and their
microenvironment. As an important regulator of intestinal microenvironment, gut microbiota …

Long known as digestive organelles, lysosomes have now emerged as multifaceted centers
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …

Recent studies have shown the importance of the dynamic tumor microenvironment (TME) in
high-grade gliomas (HGGs). In particular, myeloid cells are known to mediate …

Since the discovery of the key role of cathepsin K in bone resorption, cysteine cathepsins
have been investigated by pharmaceutical companies as drug targets. The first clinical …

Rhabdoid tumors (RTs) are genomically simple pediatric cancers driven by the biallelic
inactivation of SMARCB1, leading to SWI/SNF chromatin remodeler complex deficiency …

Cysteine cathepsins are key regulators of the innate and adaptive arms of the immune
system. Their expression, activity, and subcellular localization are associated with the …

Incidence of skeletal metastases and death from prostate cancer greatly increases with age
and obesity, conditions which increase marrow adiposity. Bone marrow adipocytes are …

Increased levels of tumor‐associated macrophages (TAMs) are indicators of poor prognosis
in most cancers. Although antibodies and small molecules blocking the recruitment of …

Lung cancer, renowned for its fast progression and metastatic potency, is rising to become a
leading cause of death globally. It has been long observed that lung cancer is particularly …

Increased bone marrow adiposity is a common feature of advanced age, obesity and
associated metabolic pathologies. Augmented numbers of marrow adipocytes positively …