Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases

OK Tørresen, B Star, P Mier… - Nucleic acids …, 2019 - academic.oup.com
The widespread occurrence of repetitive stretches of DNA in genomes of organisms across
the tree of life imposes fundamental challenges for sequencing, genome assembly, and …

A beginner's guide to eukaryotic genome annotation

M Yandell, D Ence - Nature Reviews Genetics, 2012 - nature.com
The falling cost of genome sequencing is having a marked impact on the research
community with respect to which genomes are sequenced and how and where they are …

Super-pangenome analyses highlight genomic diversity and structural variation across wild and cultivated tomato species

N Li, Q He, J Wang, B Wang, J Zhao, S Huang… - Nature Genetics, 2023 - nature.com
Effective utilization of wild relatives is key to overcoming challenges in genetic improvement
of cultivated tomato, which has a narrow genetic basis; however, current efforts to decipher …

A complete telomere-to-telomere assembly of the maize genome

J Chen, Z Wang, K Tan, W Huang, J Shi, T Li, J Hu… - Nature …, 2023 - nature.com
A complete telomere-to-telomere (T2T) finished genome has been the long pursuit of
genomic research. Through generating deep coverage ultralong Oxford Nanopore …

Protein-to-genome alignment with miniprot

H Li - Bioinformatics, 2023 - academic.oup.com
Motivation Protein-to-genome alignment is critical to annotating genes in non-model
organisms. While there are a few tools for this purpose, all of them were developed over 10 …

Dual domestications and origin of traits in grapevine evolution

Y Dong, S Duan, Q Xia, Z Liang, X Dong, K Margaryan… - Science, 2023 - science.org
We elucidate grapevine evolution and domestication histories with 3525 cultivated and wild
accessions worldwide. In the Pleistocene, harsh climate drove the separation of wild grape …

Pangenome analysis provides insight into the evolution of the orange subfamily and a key gene for citric acid accumulation in citrus fruits

Y Huang, J He, Y Xu, W Zheng, S Wang, P Chen… - Nature …, 2023 - nature.com
The orange subfamily (Aurantioideae) contains several Citrus species cultivated worldwide,
such as sweet orange and lemon. The origin of Citrus species has long been debated and …

Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet

H Yan, M Sun, Z Zhang, Y Jin, A Zhang, C Lin, B Wu… - Nature Genetics, 2023 - nature.com
Pearl millet is an important cereal crop worldwide and shows superior heat tolerance. Here,
we developed a graph-based pan-genome by assembling ten chromosomal genomes with …

[HTML][HTML] A route to de novo domestication of wild allotetraploid rice

H Yu, T Lin, X Meng, H Du, J Zhang, G Liu, M Chen… - Cell, 2021 - cell.com
Cultivated rice varieties are all diploid, and polyploidization of rice has long been desired
because of its advantages in genome buffering, vigorousness, and environmental …

A super pan-genomic landscape of rice

L Shang, X Li, H He, Q Yuan, Y Song, Z Wei, H Lin… - Cell Research, 2022 - nature.com
Pan-genomes from large natural populations can capture genetic diversity and reveal
genomic complexity. Using de novo long-read assembly, we generated a graph-based …