The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

Anorexia nervosa is a psychiatric disorder characterized by altered body image, persistent
food restriction and low body weight, and is associated with global endocrine dysregulation …

Overweight and obesity are health problems of epidemic proportions, increasing the risk not
only of cardiovascular disease and type 2 diabetes mellitus but also of various types of …

The past decade has witnessed an exponential increase in the number of publications
referring to extracellular vesicles (EVs). For many years considered to be extracellular …

Homodimeric class I cytokine receptors are assumed to exist as preformed dimers that are
activated by ligand-induced conformational changes. We quantified the dimerization of three …

In recent years, the influence of the IGF system and insulin on cancer growth has been
widely studied. Observational human studies have reported increased cancer mortality in …

Metformin is widely used in the treatment of diabetes mellitus type 2 where it reduces insulin
resistance and diabetes-related morbidity and mortality. Population-based studies show that …

Accumulating epidemiological evidence shows that being either overweight or obese, in
other words having excess body weight (EBW), is associated with an increased risk of …

The growth hormone (GH)-insulin-like growth factor (IGF) system plays a major role in
coordinating the growth of vertebrates including fish. Considerable research on the …

Background and objectives Obesity is associated with metabolic dysfunction and over
nutrition. Increased body mass index and obesity are strongly amalgamated with changes in …