Although the conventional activities of p53 such as cell cycle arrest, senescence, and
apoptosis are well accepted as the major checkpoints in stress responses, accumulating …

The increasing extension in life expectancy of human beings in developed countries is
accompanied by a progressively greater rate of degenerative diseases associated with …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They
target more than one mRNAs, thus influencing multiple molecular pathways, but also …

MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that function in regulation of
gene expression. Compelling evidences have demonstrated that miRNA expression is …

Apoptosis is a form of programmed cell death that results in the orderly and efficient removal
of damaged cells, such as those resulting from DNA damage or during development …

Prostate cancer (PC) is the third-leading cause of cancer-related deaths worldwide.
Although the current treatment strategies are progressing rapidly, PC is still representing a …

P53 is a transcription factor highly inducible by many stress signals such as DNA damage,
oncogene activation, and nutrient deprivation. Cell-cycle arrest and apoptosis are the most …

Abstract p53 is a transcription factor that suppresses tumor growth through regulation of
dozens of target genes with diverse biological functions. The activity of this master …