A small subset of B cells, termed B-1 cells, with developmental origins, phenotypes, and
functions that are distinct from those of conventional B cells exist in mice. It contributes the …

Abstract The Liver X Receptors (LXRs) are oxysterol-activated transcription factors that
upregulate a suite of genes that together promote coordinated mobilization of excess …

Background and Purpose: Atherosclerosis is an underlying cause of coronary heart disease.
Foam cell, a hallmark of atherosclerosis, is prominently derived from monocyte-differentiated …

Vascular calcification is caused by the deposition of calcium salts in the intimal or tunica
media layer of the aorta, which increases the risk of cardiovascular events and all-cause …

Rationale: Vascular microcalcification increases the risk of rupture of vulnerable
atherosclerotic lesions. Inhibition of ERK1/2 reduces atherosclerosis in animal models while …

Objective—Activation of liver X receptor (LXR) inhibits atherosclerosis but induces
hypertriglyceridemia. In vitro, it has been shown that mitogen-activated protein kinase kinase …

Aims To investigate whether activation of atheroprotective peritoneal B1a cells by apoptotic
cells or phosphatidylserine liposomes (PSLs) can enhance their protective actions during …

Cholesterol 25-hydroxylase (CH25H) catalyzes the production of 25-hydroxycholesterol (25-
HC), an oxysterol that can play an important role in different biological processes. However …

Atherosclerosis is the most common cardiovascular disease and is the number one cause of
death worldwide. Today, atherosclerosis is a multifactorial chronic inflammatory disease with …

Hepatic cholestasis can develop into liver fibrosis and eventually liver failure. Currently,
ursodeoxycholic acid (UDCA) or UDCA combined with fenofibrate is used for cholestasis …