GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease
Abstract Growth differentiation factor 15 (GDF15) is a member of the TGFβ superfamily
whose expression is increased in response to cellular stress and disease as well as by …
whose expression is increased in response to cellular stress and disease as well as by …
Exerkines in health, resilience and disease
LS Chow, RE Gerszten, JM Taylor… - Nature Reviews …, 2022 - nature.com
The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …
An exercise-inducible metabolite that suppresses feeding and obesity
Exercise confers protection against obesity, type 2 diabetes and other cardiometabolic
diseases,,,–. However, the molecular and cellular mechanisms that mediate the metabolic …
diseases,,,–. However, the molecular and cellular mechanisms that mediate the metabolic …
Exercise sustains the hallmarks of health
Y Qiu, B Fernández-García, HI Lehmann, G Li… - Journal of sport and …, 2023 - Elsevier
Exercise has long been known for its active role in improving physical fitness and sustaining
health. Regular moderate-intensity exercise improves all aspects of human health and is …
health. Regular moderate-intensity exercise improves all aspects of human health and is …
GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism
KA Sjøberg, CM Sigvardsen, A Alvarado-Diaz… - Cell metabolism, 2023 - cell.com
Summary Growth differentiation factor 15 (GDF15) induces weight loss and increases insulin
action in obese rodents. Whether and how GDF15 improves insulin action without weight …
action in obese rodents. Whether and how GDF15 improves insulin action without weight …
The role of GDF15 as a myomitokine
Growth differentiation factor 15 (GDF15) is a cytokine best known for affecting systemic
energy metabolism through its anorectic action. GDF15 expression and secretion from …
energy metabolism through its anorectic action. GDF15 expression and secretion from …
[HTML][HTML] Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist
O Benichou, T Coskun, MD Gonciarz, P Garhyan… - Cell metabolism, 2023 - cell.com
GDF15 and its receptor GFRAL/RET form a non-homeostatic system that regulates food
intake and body weight in preclinical species. Here, we describe a GDF15 analog …
intake and body weight in preclinical species. Here, we describe a GDF15 analog …
GDF15, an emerging key player in human aging
M Conte, C Giuliani, A Chiariello, V Iannuzzi… - Ageing research …, 2022 - Elsevier
Abstract Growth differentiation factor 15 (GDF15) is recently emerging not only as a stress-
related mitokine, but also as a key player in the aging process, being one of the most up …
related mitokine, but also as a key player in the aging process, being one of the most up …
Adipose tissue is a source of regenerative cells that augment the repair of skeletal muscle after injury
Q Sastourné-Arrey, M Mathieu, X Contreras… - Nature …, 2023 - nature.com
Fibro-adipogenic progenitors (FAPs) play a crucial role in skeletal muscle regeneration, as
they generate a favorable niche that allows satellite cells to perform efficient muscle …
they generate a favorable niche that allows satellite cells to perform efficient muscle …
Mitochondrial stress and mitokines in aging
Mitokines are signaling molecules that enable communication of local mitochondrial stress
to other mitochondria in distant cells and tissues. Among those molecules are FGF21 …
to other mitochondria in distant cells and tissues. Among those molecules are FGF21 …