Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential
The increase in life expectancy has boosted the incidence of age-related pathologies
beyond social and economic sustainability. Consequently, there is an urgent need for …
beyond social and economic sustainability. Consequently, there is an urgent need for …
Ceramides in metabolism: key lipotoxic players
B Chaurasia, SA Summers - Annual review of physiology, 2021 - annualreviews.org
The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …
[HTML][HTML] Physical activity/exercise and diabetes: a position statement of the American Diabetes Association
The adoption and maintenance of physical activity are critical foci for blood glucose
management and overall health in individuals with diabetes and prediabetes …
management and overall health in individuals with diabetes and prediabetes …
Update on the effects of physical activity on insulin sensitivity in humans
Purpose and methods This review presents established knowledge on the effects of physical
activity (PA) on whole-body insulin sensitivity (SI) and summarises the findings of recent …
activity (PA) on whole-body insulin sensitivity (SI) and summarises the findings of recent …
The role of ceramides in insulin resistance
E Sokolowska, A Blachnio-Zabielska - Frontiers in Endocrinology, 2019 - frontiersin.org
Resistance to insulin is a pathophysiological state related to the decreased response of
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …
Ceramides–lipotoxic inducers of metabolic disorders
B Chaurasia, SA Summers - Trends in Endocrinology & Metabolism, 2015 - cell.com
In obesity and dyslipidemia, the oversupply of fat to tissues not suited for lipid storage
induces cellular dysfunction that underlies diabetes and cardiovascular disease (ie …
induces cellular dysfunction that underlies diabetes and cardiovascular disease (ie …
Metabolic messengers: ceramides
SA Summers, B Chaurasia, WL Holland - Nature metabolism, 2019 - nature.com
Ceramides are products of metabolism that accumulate in individuals with obesity or
dyslipidaemia and alter cellular processes in response to fuel surplus. Their actions, when …
dyslipidaemia and alter cellular processes in response to fuel surplus. Their actions, when …
The lifecycle of skeletal muscle mitochondria in obesity
CA Pileggi, G Parmar, ME Harper - Obesity Reviews, 2021 - Wiley Online Library
Skeletal muscle possesses dramatic metabolic plasticity that allows for the rapid adaptation
in cellular energy transduction to meet the demands of the organism. Obesity elicits changes …
in cellular energy transduction to meet the demands of the organism. Obesity elicits changes …
Contribution of specific ceramides to obesity-associated metabolic diseases
P Hammerschmidt, JC Brüning - Cellular and Molecular Life Sciences, 2022 - Springer
Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …
Lipotoxicity plays a key role in the development of both insulin resistance and muscle atrophy in patients with type 2 diabetes
RCR Meex, EE Blaak, LJC van Loon - Obesity Reviews, 2019 - Wiley Online Library
Insulin resistance and muscle mass loss often coincide in individuals with type 2 diabetes.
Most patients with type 2 diabetes are overweight, and it is well established that obesity and …
Most patients with type 2 diabetes are overweight, and it is well established that obesity and …