Metals to combat antimicrobial resistance
Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …
Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application
Photodynamic therapy (PDT), a therapeutic mode involving light triggering, has been
recognized as an attractive oncotherapy treatment. However, nonnegligible challenges …
recognized as an attractive oncotherapy treatment. However, nonnegligible challenges …
Metallodrugs are unique: Opportunities and challenges of discovery and development
EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …
are not accessible to purely organic compounds. At least 10 metals are essential for human …
Type I photosensitizers revitalizing photodynamic oncotherapy
Photodynamic therapy (PDT) has shown great potential for tumor treatment with merits of
non‐invasiveness, high selectivity, and minimal side effects. However, conventional type II …
non‐invasiveness, high selectivity, and minimal side effects. However, conventional type II …
Ruthenium-based photoactivated chemotherapy
S Bonnet - Journal of the American Chemical Society, 2023 - ACS Publications
Ruthenium (II) polypyridyl complexes form a vast family of molecules characterized by their
finely tuned photochemical and photophysical properties. Their ability to undergo excited …
finely tuned photochemical and photophysical properties. Their ability to undergo excited …
The development of anticancer ruthenium (II) complexes: from single molecule compounds to nanomaterials
Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …
Critical overview of the use of Ru (II) polypyridyl complexes as photosensitizers in one-photon and two-photon photodynamic therapy
Conspectus Photodynamic Therapy (PDT) is an emerging technique to treat certain types of
cancer, bacterial, fungal, and viral infections, and skin diseases. In past years, different …
cancer, bacterial, fungal, and viral infections, and skin diseases. In past years, different …
Photodynamic therapy for cancer: what's past is prologue
MR Hamblin - Photochemistry and photobiology, 2020 - Wiley Online Library
Abstract Thomas J Dougherty from Roswell Park Cancer Center played a major role in the
progress of photodynamic therapy (PDT) from a laboratory science into a real‐world clinical …
progress of photodynamic therapy (PDT) from a laboratory science into a real‐world clinical …
The development of ruthenium (II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications
Ruthenium (II)[Ru (II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years …
since work began exploring their supramolecular interactions with DNA. In recent years …
Transition metal complexes as photosensitisers in one-and two-photon photodynamic therapy
Photodynamic therapy (PDT) exploits light-activated compounds for therapeutic use. It relies
on a photosensitiser (PS) that is inactive in the absence of light. When irradiated, the PS …
on a photosensitiser (PS) that is inactive in the absence of light. When irradiated, the PS …