In addition to the canonical right-handed double helix, other DNA structures, termed 'non-B
DNA', can form in the genomes across the tree of life. Non-B DNA regulates multiple cellular …

Despite the efforts that bioengineers have exerted in designing and constructing biological
processes that function according to a predetermined set of rules, their operation remains …

Bacteria use complex strategies to coordinate temperature-dependent gene expression.
Many genes encoding heat shock proteins and virulence factors are regulated by …

The heat-shock response is a mechanism of cellular protection against sudden adverse
environmental growth conditions and results in the prompt production of various heat-shock …

The effect of the bacterial heat-stable nucleoid-structuring (H-NS) protein on gene
expression is overwhelmingly negative and extends throughout the genome, pointing to an …

The bacterial chromosomal DNA is folded into a compact structure called nucleoid. The
shape and size of this 'body'is determined by a number of factors. Major players are DNA …

Lateral gene transfer has played a prominent role in bacterial evolution, but the mechanisms
allowing bacteria to tolerate the acquisition of foreign DNA have been incompletely defined …

Two recent reports have indicated that the H-NS protein in Salmonella enterica serovar
Typhimurium has a key role in selectively silencing the transcription of large numbers of …

Efflux pumps represent an important and large group of transporter proteins found in all
organisms. The importance of efflux pumps resides in their ability to extrude a wide range of …

The H-NS nucleoid-associated DNA-binding protein is an important global repressor of
transcription in Gram-negative bacteria. Recently, H-NS has been implicated in the process …