Heat shock 70 kDa proteins (HSP70s) are ubiquitous molecular chaperones that function in
a myriad of biological processes, modulating polypeptide folding, degradation and …

Emerging evidence indicates that heat shock proteins (HSPs) are critical regulators in
normal neural physiological function as well as in cell stress responses. The functions of …

Misfolding and aggregation are associated with cytotoxicity in several protein folding
diseases. A large network of molecular chaperones ensures protein quality control. Here, we …

Abstract CDK12 (cyclin-dependent kinase 12) is a regulatory kinase with evolutionarily
conserved roles in modulating transcription elongation. Recent tumor genome studies of …

Maintenance of protein homeostasis is vitally important in post-mitotic cells, particularly
neurons. Neurodegenerative diseases such as polyglutamine expansion disorders—like …

A small number of heat-shock proteins have previously been shown to act protectively on
aggregation of several proteins containing an extended polyglutamine (polyQ) stretch, which …

Objective: To identify the causative gene in an autosomal dominant limb‐girdle muscular
dystrophy (LGMD) with skeletal muscle vacuoles. Methods: Exome sequencing was used to …

Skeletal muscle and the nervous system depend on efficient protein quality control, and they
express chaperones and cochaperones at high levels to maintain protein homeostasis …

Expanded polyglutamine (polyQ) stretches lead to protein aggregation and severe
neurodegenerative diseases. A highly efficient suppressor of polyQ aggregation was …

Protein misfolding and aggregation are associated with many neurodegenerative diseases,
including Huntington's disease. The cellular machinery for maintaining proteostasis includes …