The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …

Improved understanding of genetic regulation of the proteome can facilitate identification of
the causal mechanisms for complex traits. We analyzed data on 4,657 plasma proteins from …

The Mendelian randomization (MR) paradigm allows for causal inferences to be drawn
using genetic data. In recent years, the expansion of well-powered publicly available genetic …

Background: The SOMAscan assay has an advantage over immunoassay-based methods
because it measures a large number of proteins in a cost-effective manner. However, the …

Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease
(AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a …

Despite the identification of a growing number of genetic risk loci for substance use traits
(SUTs), the impact of these loci on protein abundance and the potential utility of relevant …

Improved understanding of the genetic architecture of the proteome through studies of larger
sample size, ethnic diversity, and advanced methods can facilitate the identification of …

The study of parental lifespan has emerged as an innovative tool to advance aging biology
and our understanding of the genetic architecture of human longevity and aging‐associated …

Alpha-synuclein is the main protein component of Lewy bodies, the pathological hallmark of
Parkinson's disease. However, genetic modifiers of cerebrospinal fluid (CSF) alpha …

Common and rare variants in the LRRK2 locus are associated with Parkinson's disease
(PD) risk, but the downstream effects of these variants on protein levels remains unknown …