The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …

Genomic imprinting affects several dozen mammalian genes and results in the expression of
those genes from only one of the two parental chromosomes. This is brought about by …

Clonally expanded blood cells that contain somatic mutations (clonal haematopoiesis) are
commonly acquired with age and increase the risk of blood cancer,,,,,,,–. The blood clones …

Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …

We suggest a model in which a hierarchy of controls is exerted on the family of odorant
receptor genes to assure that a sensory neuron expresses a single receptor from a family of …

▪ Abstract The separation of sister chromatids at the metaphase to anaphase transition is
one of the most dramatic of all cellular events and is a crucial aspect of all sexual and …

The tripartite toxin secreted by Bacillus anthracis, the causative agent of anthrax, helps the
bacterium evade the immune system and can kill the host during a systemic infection. Two …

The H19 gene is imprinted with preferential expression from the maternal allele. The
putative imprinting control region for this locus is hypermethylated on the repressed paternal …

▪ Abstract The MCM proteins are essential replication initiation factors originally identified as
proteins required for minichromosome maintenance in Saccharomyces cerevisiae. The best …

The chromosomal region, 15q11-q13, involved in Prader-Willi and Angelman syndromes
(PWS and AS) represents a paradigm for understanding the relationships between genome …