Albumin is the most abundant circulating protein in plasma and has recently emerged as a
versatile protein carrier for drug targeting and for improving the pharmacokinetic profile of …

Liver fibrosis is defined as excessive extracellular matrix deposition and is based on
complex interactions between matrix-producing hepatic stellate cells and an abundance of …

Among serum proteins albumin and transferrin have attracted the most interest as drug
carriers in the past two decades. Prior to that, their potential use was overshadowed by the …

Myofibroblasts are the key players in extracellular matrix remodeling, a core phenomenon in
numerous devastating fibrotic diseases. Not only in organ fibrosis, but also the pivotal role of …

Albumin is a biocompatible, non-immunogenic and versatile drug carrier system. It has been
widely used to extend the half-life, enhance stability, provide protection from degradation …

Liver fibrosis is caused by excessive accumulation of extracellular matrix during chronic liver
injuries. Although clinical evidence suggests that liver fibrosis can be reversed, there is no …

Hepatic fibrosis, characterized by excessive accumulation of extracellular matrix (ECM)
proteins leading to liver dysfunction, is a growing cause of mortality worldwide …

Renal fibrosis leads to end-stage renal disease demanding renal replacement therapy
because no adequate treatment exists. IFN-γ is an antifibrotic cytokine that may attenuate …

Since they were first reported in 1980, site-specific drug delivery nanocarriers have
progressed greatly with the development of nanotechnology and biotechnology, especially …

Cytokines, growth factors, and other locally produced mediators play key roles in the
regulation of disease progression. During liver fibrosis, these mediators orchestrate the …