Over the last decade, significant progress has been made in the field of drug delivery. The
advent of engineered nanoparticles has allowed us to circumvent the initial limitations to …

Until recently most studies of metastasis only measured the end point of the process—
macroscopic metastases. Although these studies have provided much useful information …

Despite the high doses of radiation delivered in the treatment of patients with glioblastoma
multiforme (GBM), the tumors invariably recur within the irradiation field, resulting in a low …

In preclinical cancer research, bioluminescence imaging with firefly luciferase and d-luciferin
has become a standard to monitor biological processes both in vitro and in vivo. However …

Hypoxia, a condition of insufficient O 2 to support metabolism, occurs when the vascular
supply is interrupted, as in stroke or myocardial infarction, or when a tumor outgrows its …

Abstract Hypoxia-inducible factor 1 (HIF-1) plays a role in tumour metastases; however, the
genes that activate HIF-1 and subsequently promote metastases have yet to be identified …

In vivo bioluminescent imaging (BLI) is increasingly being utilized as a method for modern
biological research. This process, which involves the noninvasive interrogation of living …

A tumor‐specific microenvironment is characterized by hypoxia, in which oxygen tension is
considerably lower than in normal tissues. The hypoxic status of various solid tumors has …

Local recurrence and distant metastasis frequently occur after radiation therapy for cancer
and can be fatal. Evidence obtained from radiochemical and radiobiological studies has …

Tumour recurrence frequently occurs after radiotherapy, but the characteristics,
intratumoural localization and post-irradiation behaviour of radioresistant cancer cells …