Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

Emerging clinical evidence shows that the deregulation of ubiquitin-mediated degradation of
oncogene products or tumour suppressors is likely to be involved in the aetiology of …

Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …

Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-
translational modification. However, a potent and selective inhibitor targeting the SUMO …

Zinc finger proteins containing the Kruppel associated box (KRAB-ZFPs) constitute the
largest individual family of transcriptional repressors encoded by the genomes of higher …

DNA non-homologous end-joining (NHEJ) and homologous recombination (HR) represent
the major DNA double strand break (DSB) pathways in mammalian cells, whilst ataxia …

DNA double-strand breaks (DSBs) trigger ATM (ataxia telangiectasia mutated) signalling
and elicit genomic rearrangements and chromosomal fragmentation if misrepaired or …

KAP-1 poses a substantial barrier to DNA double-strand break (DSB) repair within
heterochromatin that is alleviated by ATM-dependent KAP-1 phosphorylation (pKAP-1) …

SUMOylation is an essential modification that regulates hundreds of proteins in eukaryotic
cells. Owing to its dynamic nature and low steady-state levels, endogenous SUMOylation is …

Sumoylation is an essential post-translational modification that has evolved to regulate
intricate networks within emerging complexities of eukaryotic cells. Thousands of target …