Origin and function of the yolk sac in primate embryogenesis
C Ross, TE Boroviak - Nature communications, 2020 - nature.com
Human embryogenesis is hallmarked by two phases of yolk sac development. The primate
hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a …
hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a …
Tissue mechanics in stem cell fate, development, and cancer
Cells in tissues experience a plethora of forces that regulate their fate and modulate
development and homeostasis. Cells sense mechanical cues through localized …
development and homeostasis. Cells sense mechanical cues through localized …
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
The role of cellular metabolism in regulating cell proliferation and differentiation remains
poorly understood. For example, most mammalian cells cannot proliferate without …
poorly understood. For example, most mammalian cells cannot proliferate without …
[HTML][HTML] Single-cell landscape of transcriptional heterogeneity and cell fate decisions during mouse early gastrulation
H Mohammed, I Hernando-Herraez, A Savino… - Cell reports, 2017 - cell.com
The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE)
lineages coincident with implantation of the embryo. The epiblast subsequently undergoes …
lineages coincident with implantation of the embryo. The epiblast subsequently undergoes …
[HTML][HTML] Membrane tension gates ERK-mediated regulation of pluripotent cell fate
Cell fate transitions are frequently accompanied by changes in cell shape and mechanics.
However, how cellular mechanics affects the instructive signaling pathways controlling cell …
However, how cellular mechanics affects the instructive signaling pathways controlling cell …
Lineage-specific profiling delineates the emergence and progression of naive pluripotency in mammalian embryogenesis
Naive pluripotency is manifest in the preimplantation mammalian embryo. Here we
determine transcriptome dynamics of mouse development from the eight-cell stage to …
determine transcriptome dynamics of mouse development from the eight-cell stage to …
[HTML][HTML] Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells
K Hayashi, H Ohta, K Kurimoto, S Aramaki, M Saitou - Cell, 2011 - cell.com
The generation of properly functioning gametes in vitro requires reconstitution of the
multistepped pathway of germ cell development. We demonstrate here the generation of …
multistepped pathway of germ cell development. We demonstrate here the generation of …
Establishment of mouse expanded potential stem cells
Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and
the germline but are excluded from the extra-embryonic tissues that are derived from the …
the germline but are excluded from the extra-embryonic tissues that are derived from the …
Lineage specification in the mouse preimplantation embryo
C Chazaud, Y Yamanaka - Development, 2016 - journals.biologists.com
During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …
The nature of embryonic stem cells
G Martello, A Smith - Annual review of cell and developmental …, 2014 - annualreviews.org
Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …