Human embryogenesis is hallmarked by two phases of yolk sac development. The primate
hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a …

Cells in tissues experience a plethora of forces that regulate their fate and modulate
development and homeostasis. Cells sense mechanical cues through localized …

The role of cellular metabolism in regulating cell proliferation and differentiation remains
poorly understood. For example, most mammalian cells cannot proliferate without …

The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE)
lineages coincident with implantation of the embryo. The epiblast subsequently undergoes …

Cell fate transitions are frequently accompanied by changes in cell shape and mechanics.
However, how cellular mechanics affects the instructive signaling pathways controlling cell …

Naive pluripotency is manifest in the preimplantation mammalian embryo. Here we
determine transcriptome dynamics of mouse development from the eight-cell stage to …

The generation of properly functioning gametes in vitro requires reconstitution of the
multistepped pathway of germ cell development. We demonstrate here the generation of …

Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and
the germline but are excluded from the extra-embryonic tissues that are derived from the …

During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …

Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …